Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model
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چکیده
منابع مشابه
Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model
BACKGROUND Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and unpredictable side effect. It is essential to establish an efficient and safe protocol for the administration of CPT versus melanoma. METHODS Camptothecin was encapsulated with ...
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Camptothecin (CPT) exhibits very strong antitumor effects by inhibiting the activity of DNA topoisomerase I, but its application is greatly limited due to its low solubility and the instability of the active lactone form. To overcome these shortcomings, in the present study, we prepared novel camptothecin nanocolloids based on N,N,N-trimethyl chitosan (CPT-TMC) to efficiently and safely adminis...
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Lymphatic metastasis plays a critical role in ovarian cancer, indicates poor prognoses and correlates to the majority of cancer deaths. Camptothecin derivatives exhibit promising activity for the treatment of solid tumors because of its specific inhibition of eukaryotic DNA topoisomerase I. Yet, its application is hindered due to extreme water insolubility and severe side effects. It is essenti...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2010
ISSN: 1756-9966
DOI: 10.1186/1756-9966-29-76